Mlb Grand Slam Leaders 2025. Manny machado has launched the most career grand slams by an active player, with 12 grand slams. 1030 rows listed below are the top 1,000 grand slam hitters in major leauge history, players that made it their career terrorizing pitchers when they stepped to the plate.

Manny machado has launched the most career grand slams by an active player, with 12 grand slams. This is a comprehensive breakdown of both leagues showing the number of grand slams in each league and a major.